Photophobia in essential blepharospasm—A positron emission tomographic study
Identifieur interne : 001B05 ( Main/Exploration ); précédent : 001B04; suivant : 001B06Photophobia in essential blepharospasm—A positron emission tomographic study
Auteurs : Hirofumi Emoto [Japon] ; Yukihisa Suzuki [Japon] ; Masato Wakakura [Japon] ; Chiharu Horie [Japon] ; Motohiro Kiyosawa [Japon] ; Manabu Mochizuki [Japon] ; Keiichi Kawasaki [Japon] ; Keiichi Oda [Japon] ; Kiichi Ishiwata [Japon] ; Kenji Ishii [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-03-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Blepharospasm, Blepharospasm (psychology), Colliculus superior, Emission tomography, Female, Fluorodeoxyglucose F18 (diagnostic use), Humans, Male, Middle Aged, Nerve Net (physiopathology), Nervous system diseases, Neural Pathways (physiopathology), Occipital Lobe (physiopathology), Photophobia (diagnosis), Photophobia (etiology), Photophobia (physiopathology), Positron, Positron emission tomography, Positron-Emission Tomography, Radiopharmaceuticals (diagnostic use), Thalamus, Thalamus (physiopathology), Trigeminal Nerve (physiopathology), essential blepharospasm, photophobia, positron emission tomography, superior colliculus, thalamus.
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- diagnosis : Photophobia.
- etiology : Photophobia.
- physiopathology : Nerve Net, Neural Pathways, Occipital Lobe, Photophobia, Thalamus, Trigeminal Nerve.
- psychology : Blepharospasm.
- Adult, Female, Humans, Male, Middle Aged, Positron-Emission Tomography.
Abstract
To localize regional alterations in cerebral glucose metabolism in essential blepharospasm (EB) patients with photophobia. We have studied 22 EB patients by performing positron emission tomography and [18F]‐fluorodeoxyglucose analysis. The patients were classified into two subgroups, namely, EB with photophobia (P group) and EB without photophobia (NP group), and compared with a healthy control group (n = 44). There were no significant differences between the two patient groups with respect to the severity of motor symptoms or the duration for which the condition persisted. The FDG‐PET images were analyzed using the statistical parametric mapping software. As compared to the control group, the P group exhibited significant hypermetabolism in the thalamus (P = 0.002), while the NP group exhibited significant hypometabolism in the dorsal midbrain, especially, in the superior colliculus (P = 0.005). The P group exhibited significant hypermetabolism in the thalamus and the dorsal midbrain as compared to the NP group (P < 0.001). These findings suggest that photophobia in EB patients may be associated with abnormal hyperactivity in the thalamus. Either hyperactivity of the thalamus or hypoactivity of the superior colliculus, or both may be associated with excessive blinking in these patients. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22916
Affiliations:
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wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuro‐Ophthalmology, Inouye Eye Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Horie, Chiharu" sort="Horie, Chiharu" uniqKey="Horie C" first="Chiharu" last="Horie">Chiharu Horie</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Kiyosawa, Motohiro" 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-03-15">2010-03-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="433">433</biblScope><biblScope unit="page" to="439">439</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2AFCF40C8FB75C7606787E59A6D482D49C1EC6A2</idno><idno type="DOI">10.1002/mds.22916</idno><idno type="ArticleID">MDS22916</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Blepharospasm</term><term>Blepharospasm (psychology)</term><term>Colliculus superior</term><term>Emission tomography</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nerve Net (physiopathology)</term><term>Nervous system diseases</term><term>Neural Pathways (physiopathology)</term><term>Occipital Lobe (physiopathology)</term><term>Photophobia (diagnosis)</term><term>Photophobia (etiology)</term><term>Photophobia (physiopathology)</term><term>Positron</term><term>Positron emission tomography</term><term>Positron-Emission Tomography</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Thalamus</term><term>Thalamus (physiopathology)</term><term>Trigeminal Nerve (physiopathology)</term><term>essential blepharospasm</term><term>photophobia</term><term>positron emission tomography</term><term>superior colliculus</term><term>thalamus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Photophobia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Photophobia</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Nerve Net</term><term>Neural Pathways</term><term>Occipital Lobe</term><term>Photophobia</term><term>Thalamus</term><term>Trigeminal Nerve</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Blepharospasm</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Blépharospasme</term><term>Pathologie du système nerveux</term><term>Positon</term><term>Thalamus</term><term>Tomographie par émission de positons</term><term>Tomoscintigraphie</term><term>Tubercule quadrijumeau antérieur</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To localize regional alterations in cerebral glucose metabolism in essential blepharospasm (EB) patients with photophobia. We have studied 22 EB patients by performing positron emission tomography and [18F]‐fluorodeoxyglucose analysis. The patients were classified into two subgroups, namely, EB with photophobia (P group) and EB without photophobia (NP group), and compared with a healthy control group (n = 44). There were no significant differences between the two patient groups with respect to the severity of motor symptoms or the duration for which the condition persisted. The FDG‐PET images were analyzed using the statistical parametric mapping software. As compared to the control group, the P group exhibited significant hypermetabolism in the thalamus (P = 0.002), while the NP group exhibited significant hypometabolism in the dorsal midbrain, especially, in the superior colliculus (P = 0.005). The P group exhibited significant hypermetabolism in the thalamus and the dorsal midbrain as compared to the NP group (P < 0.001). These findings suggest that photophobia in EB patients may be associated with abnormal hyperactivity in the thalamus. Either hyperactivity of the thalamus or hypoactivity of the superior colliculus, or both may be associated with excessive blinking in these patients. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Emoto, Hirofumi" sort="Emoto, Hirofumi" uniqKey="Emoto H" first="Hirofumi" last="Emoto">Hirofumi Emoto</name></noRegion><name sortKey="Emoto, Hirofumi" sort="Emoto, Hirofumi" uniqKey="Emoto H" first="Hirofumi" last="Emoto">Hirofumi Emoto</name><name sortKey="Horie, Chiharu" sort="Horie, Chiharu" uniqKey="Horie C" first="Chiharu" last="Horie">Chiharu Horie</name><name sortKey="Horie, Chiharu" sort="Horie, Chiharu" uniqKey="Horie C" first="Chiharu" last="Horie">Chiharu Horie</name><name sortKey="Ishii, Kenji" sort="Ishii, Kenji" uniqKey="Ishii K" first="Kenji" last="Ishii">Kenji Ishii</name><name sortKey="Ishiwata, Kiichi" sort="Ishiwata, Kiichi" uniqKey="Ishiwata K" first="Kiichi" last="Ishiwata">Kiichi Ishiwata</name><name sortKey="Kawasaki, Keiichi" sort="Kawasaki, Keiichi" uniqKey="Kawasaki K" first="Keiichi" last="Kawasaki">Keiichi Kawasaki</name><name sortKey="Kiyosawa, Motohiro" sort="Kiyosawa, Motohiro" uniqKey="Kiyosawa M" first="Motohiro" last="Kiyosawa">Motohiro Kiyosawa</name><name sortKey="Mochizuki, Manabu" sort="Mochizuki, Manabu" uniqKey="Mochizuki M" first="Manabu" last="Mochizuki">Manabu Mochizuki</name><name sortKey="Oda, Keiichi" sort="Oda, Keiichi" uniqKey="Oda K" first="Keiichi" last="Oda">Keiichi Oda</name><name sortKey="Suzuki, Yukihisa" sort="Suzuki, Yukihisa" uniqKey="Suzuki Y" first="Yukihisa" last="Suzuki">Yukihisa Suzuki</name><name sortKey="Suzuki, Yukihisa" sort="Suzuki, Yukihisa" uniqKey="Suzuki Y" first="Yukihisa" last="Suzuki">Yukihisa Suzuki</name><name sortKey="Wakakura, Masato" sort="Wakakura, Masato" uniqKey="Wakakura M" first="Masato" last="Wakakura">Masato Wakakura</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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